PTPN13

Across TCGA pan-cancer cohorts, PTPN13 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PTPN13 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PTPN13 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPN13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, HNSC, and KIRC are the cancer types where PTPN13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.392	0.780	<.001	111	view →
HNSC	DFS	Tertile	All	0.704	0.505	<.001	96	view →
KIRC	DFS	Median	All	0.720	0.545	<.001	84	view →
UCEC	DFS	Tertile	All	0.764	0.901	<.001	70	view →
LGG	OS	Median	All	0.350	0.560	<.001	54	view →
MESO	OS	Quartile	II,III,IV	0.546	0.769	.002	50	view →
LAML	DFS	Median	All	0.495	0.257	<.001	42	view →
STAD	OS	Tertile	All	0.543	0.668	.017	27	view →
PAAD	OS	Tertile	II,III,IV	0.450	0.737	.003	24	view →
SCLC	DFS	Median	II,III,IV	0.690	0.493	.020	18	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	15	view →
LIHC	DFS	Median	III,IV	0.592	0.213	<.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PTPN13–UVM (DFS)

Open the UVM breakdown →