PTPN13

Across TCGA patient cohorts, PTPN13 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN13-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and eIF4E. Each is linked with PTPN13 in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPN13-to-partner and partner-to-PTPN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PTPN13-low versus PTPN13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN13→partner) and Y-score (partner→PTPN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.200	+1.624	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+0.887	+2.906	<.001	.001	3	4
STAD	eIF4E →	+0.178	+2.584	.018	.010	3	3
STAD	p90 RSK →	+0.281	+3.000	.007	.033	3	3
COAD	ATM →	-0.383	-1.874	.002	.047	3	3
STAD	FASN →	+0.548	+2.185	.001	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

PCNA by PTPN13 expression — UCEC

Explore this box plot interactively →