PTPN13

Across TCGA cell cohorts, PTPN13 mutation is significantly associated with the RNA expression of many other genes, with 724 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPN13-associated genes across cancer lineages are EVX2, KCNA4, and TMEM89. Each is linked with PTPN13 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN13-to-partner and partner-to-PTPN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVX2 grouped by PTPN13-low versus PTPN13-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN13→partner) and Y-score (partner→PTPN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EVX2 →	+0.033	+3.491	<.001	<.001	3	2
OVARY	KCNA4 →	+0.130	+2.752	.001	.003	3	2
OVARY	TMEM89 →	+0.078	+3.269	.002	.004	3	2
BLOOD_Leukemia	DMRTC1 →	+0.152	+2.078	<.001	.006	3	2
LARGE_INTESTINE	SRPX2 →	-1.298	-2.179	.002	.004	3	2
LARGE_INTESTINE	IL7 →	+0.634	+3.247	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 724 associations by consensus.

EVX2 by PTPN13 expression — OVARY

Explore this box plot interactively →