PTPN12

Across TCGA pan-cancer cohorts, PTPN12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTPN12 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PTPN12 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPN12 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where PTPN12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.920	0.384	.006	30	view →
PDAC	DFS	Median	All	0.694	0.832	.003	16	view →
CCRCC	OS	Tertile	All	0.459	0.982	.006	14	view →
COAD	DFS	Quartile	All	0.832	1.000	.042	6	view →
GBM	OS	Tertile	All	0.734	0.900	.021	3	view →
LUAD	OS	Quartile	All	1.000	0.938	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTPN12–UCEC (DFS)

Open the UCEC breakdown →