PTPN12

Across TCGA pan-cancer cohorts, PTPN12 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PTPN12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTPN12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPN12 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where PTPN12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPN12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.849	<.001	12	view →
KIRC	Male	All	+1.132	<.001	11	view →
LIHC	Female	II,III,IV	+1.099	<.001	9	view →
COAD	Male	II,III,IV	+0.887	<.001	9	view →
KIRP	All	II,III,IV	+0.828	<.001	9	view →
READ	All	All	+0.726	.002	6	view →
CHOL	Male	All	+2.500	<.001	5	view →
KICH	Female	All	−1.260	<.001	5	view →
STAD	All	II,III,IV	+0.953	.001	5	view →
BLCA	All	All	+0.352	.040	4	view →
BRCA	All	II,III,IV	+0.303	<.001	4	view →
LUAD	All	All	−0.212	.024	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PTPN12–HNSC

Open the HNSC breakdown →