PTPN12

Across TCGA patient cohorts, PTPN12 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,400 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN12-associated proteins across cancer lineages are ATP5PB, PTPN12_S332, and CEP170. Each is linked with PTPN12 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPN12-to-partner and partner-to-PTPN12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN12 versus ATP5PB in PDAC, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN12→partner) and Y-score (partner→PTPN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ATP5PB →	-0.345	-0.247	<.001	.004	3	6
GBM	PTPN12_S332 →	+0.664	+0.475	<.001	<.001	3	5
COAD	CEP170 →	+0.241	+0.428	.003	<.001	3	5
GBM	ITGA5 →	+0.525	+0.449	<.001	.001	3	5
OV	HIP1 →	+0.347	+0.653	.001	<.001	3	4
BRCA	MBLAC2 →	-0.455	-0.564	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,400 associations by consensus.

PTPN12 vs ATP5PB — PDAC

Explore this scatter interactively →