PTPN12

Across TCGA patient cohorts, PTPN12 protein abundance is significantly associated with the RNA expression of many other genes, with 19,664 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN12-associated genes across cancer lineages are PLAUR, CALU, and YWHAG. Each is linked with PTPN12 in more than 7 cancer types. Because this analysis shows association rather than direction, both PTPN12-to-partner and partner-to-PTPN12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN12 versus PLAUR in OV, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN12→partner) and Y-score (partner→PTPN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLAUR →	+0.861	+0.220	.006	.006	3	8
CCRCC	CALU →	+0.759	+0.315	<.001	<.001	3	8
BRCA	YWHAG →	+0.645	+0.244	<.001	.001	3	7
COAD	LINC01614 →	+1.577	+0.326	<.001	<.001	3	7
LUAD	SPATA20P1 →	+1.137	+0.258	<.001	<.001	3	7
UCEC	TBL2 →	+0.714	+0.234	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,664 associations by consensus.

PTPN12 vs PLAUR — OV

Explore this scatter interactively →