PTPN12

Across TCGA patient cohorts, PTPN12 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN12-associated genes across cancer lineages are mTOR_pS2448, ATM, and 4E-BP1_pT37_T46. Each is linked with PTPN12 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN12-to-partner and partner-to-PTPN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PTPN12-low versus PTPN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN12→partner) and Y-score (partner→PTPN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.159	-2.247	.003	.001	3	3
UCEC	ATM →	-0.695	-2.247	<.001	.001	3	3
UCEC	4E-BP1_pT37_T46 →	-0.309	-1.861	.025	.049	3	2
UCEC	eIF4E →	+0.161	+2.335	.037	.018	3	1
UCEC	MEK1 →	+0.435	+2.700	.001	.005	3	1
UCEC	MSH2 →	-0.247	-2.558	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

mTOR_pS2448 by PTPN12 expression — UCEC

Explore this box plot interactively →