PTPN12

Across TCGA cell cohorts, PTPN12 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN12-associated genes across cancer lineages are CRYGC, RESP18, and CCER1. Each is linked with PTPN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN12-to-partner and partner-to-PTPN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGC grouped by PTPN12-low versus PTPN12-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN12→partner) and Y-score (partner→PTPN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CRYGC →	+0.083	+4.643	<.001	.008	3	1
BREAST	RESP18 →	+0.072	+5.169	<.001	.005	3	1
CNS	CCER1 →	+0.016	+5.754	<.001	.002	3	1
LARGE_INTESTINE	ASPN →	+0.031	+2.426	.002	.005	3	1
LARGE_INTESTINE	ZNF189 →	+0.514	+2.451	.001	.009	3	1
LARGE_INTESTINE	RPS8 →	+0.493	+3.502	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

CRYGC by PTPN12 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →