PTPN11

Across TCGA patient cohorts, PTPN11 RNA expression is significantly associated with the RNA expression of many other genes, with 20,247 significant associations in total. THYM shows the largest number of these associations.

The most reproducible PTPN11-associated genes across cancer lineages are TSHZ1, MED14, and ZNF609. Each is linked with PTPN11 in more than 33 cancer types. Because this analysis shows association rather than direction, both PTPN11-to-partner and partner-to-PTPN11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN11 versus TSHZ1 in DLBC, with a Pearson correlation of 0.88.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN11→partner) and Y-score (partner→PTPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TSHZ1 →	+1.774	+1.602	<.001	<.001	3	34
DLBC	MED14 →	+1.756	+1.806	<.001	<.001	3	34
DLBC	ZNF609 →	+1.532	+1.806	<.001	<.001	3	34
DLBC	POLR2A →	+1.642	+1.666	<.001	<.001	3	34
DLBC	SETD2 →	+1.212	+1.448	<.001	<.001	3	34
UVM	RFX7 →	+1.270	+1.673	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,247 associations by consensus.

PTPN11 vs TSHZ1 — DLBC

Explore this scatter interactively →