PTPA

Across TCGA patient cohorts, PTPA mutation is significantly associated with the RNA expression of many other genes, with 1,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPA-associated genes across cancer lineages are EIF1, RNU6-1181P, and RNU6-903P. Each is linked with PTPA in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPA-to-partner and partner-to-PTPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF1 grouped by PTPA-low versus PTPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPA→partner) and Y-score (partner→PTPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF1 →	+0.298	+1.797	.009	.008	3	2
HNSC	RNU6-1181P →	+0.524	+6.008	<.001	.002	3	2
SKCM	RNU6-903P →	+0.196	+2.715	.008	.004	3	2
LIHC	RNU6-750P →	+0.220	+5.317	<.001	.002	3	2
LIHC	RN7SKP42 →	+0.090	+4.423	<.001	.007	3	2
LIHC	USP17L1 →	+0.018	+4.423	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,130 associations by consensus.

EIF1 by PTPA expression — UCEC

Explore this box plot interactively →