PTPA

Across TCGA pan-cancer cohorts, PTPA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PTPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PTPA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPA is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where PTPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.429	<.001	11	view →
COAD	Female	II,III,IV	+0.445	<.001	10	view →
LIHC	All	II,III,IV	+0.674	<.001	8	view →
HNSC	All	All	+0.336	<.001	8	view →
KICH	Male	All	−0.980	<.001	7	view →
BRCA	All	III,IV	+0.861	<.001	6	view →
STAD	All	II,III,IV	+0.674	<.001	6	view →
KIRP	All	All	+0.459	.002	6	view →
CHOL	All	All	+1.632	<.001	4	view →
LUSC	All	All	+0.269	.001	3	view →
LUAD	All	IV	+0.120	.042	2	view →
ESCA	All	All	+0.759	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PTPA–KIRC

Open the KIRC breakdown →