PTPA

Across TCGA patient cohorts, PTPA mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPA-associated genes across cancer lineages are MSH2, EGFR_pY1068, and Notch1. Each is linked with PTPA in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPA-to-partner and partner-to-PTPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PTPA-low versus PTPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPA→partner) and Y-score (partner→PTPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.320	-3.143	<.001	.018	3	3
UCEC	EGFR_pY1068 →	-0.243	-2.321	.019	.006	3	2
UCEC	Notch1 →	+0.156	+2.009	.007	.017	3	2
UCEC	SF2 →	-0.142	-2.574	.001	.010	3	2
UCEC	c-Jun_pS73 →	-0.147	-3.156	.025	.018	3	2
UCEC	ER-alpha_pS118 →	-0.367	-3.584	.013	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MSH2 by PTPA expression — UCEC

Explore this box plot interactively →