PTN

Across TCGA pan-cancer cohorts, PTN mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PTN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTN mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PTN is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where PTN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.011	<.001	12	view →
HNSC	Male	IV	−2.096	<.001	11	view →
CCRCC	Male	III,IV	−1.931	<.001	11	view →
LUAD	Female	All	−1.292	<.001	9	view →
LSCC	All	III,IV	−1.010	<.001	9	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PTN–COAD

Open the COAD breakdown →