PTN

Across TCGA pan-cancer cohorts, PTN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PTN data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PTN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTN expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

LGG, UVM, and BLCA are the cancer types where PTN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.735	0.880	<.001	46	view →
UVM	DFS	Tertile	III,IV	0.184	1.000	.002	36	view →
BLCA	OS	Median	II,III,IV	0.666	0.767	.009	34	view →
KIRP	DFS	Tertile	All	0.941	0.794	<.001	30	view →
KIRC	DFS	Median	III,IV	0.578	0.360	.008	24	view →
ACC	DFS	Tertile	III,IV	0.272	0.716	.002	23	view →
ESCA	OS	Median	All	1.000	0.629	.012	21	view →
SCLC	OS	Median	All	0.575	1.000	.004	19	view →
PRAD	DFS	Median	All	0.870	0.717	.002	18	view →
LUSC	OS	Median	All	0.818	0.730	.010	17	view →
THCA	OS	Median	III,IV	0.894	0.988	.004	17	view →
BRCA	OS	Median	III,IV	0.671	0.324	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PTN–LGG (OS)

Open the LGG breakdown →