PTN

Across TCGA patient cohorts, PTN mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTN-associated genes across cancer lineages are C-Raf, HER3_pY1289, and JNK2. Each is linked with PTN in more than 2 cancer types. Because this analysis shows association rather than direction, both PTN-to-partner and partner-to-PTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PTN-low versus PTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTN→partner) and Y-score (partner→PTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.273	+3.906	<.001	<.001	3	3
UCEC	HER3_pY1289 →	+0.074	+1.833	.038	.016	3	2
UCEC	JNK2 →	+0.339	+3.469	<.001	.002	3	2
UCEC	MEK1 →	+0.468	+3.807	.001	<.001	3	2
UCEC	P-Cadherin →	-0.172	-3.574	.003	.002	3	2
UCEC	PDCD4 →	-0.721	-3.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

C-Raf by PTN expression — UCEC

Explore this box plot interactively →