PTN

Across TCGA cell cohorts, PTN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,077 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTN-associated GO terms across cancer lineages are Regulation of intracellular transport, Positive regulation of intracellular transport, and Regulation of intracellular protein transport. Each is linked with PTN in more than 11 cancer types. Because this analysis shows association rather than direction, both PTN-to-partner and partner-to-PTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular transport grouped by PTN-low versus PTN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTN→partner) and Y-score (partner→PTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of intracellular transport →	+0.064	+5.152	<.001	<.001	3	12
LIVER	Positive regulation of intracellular transport →	+0.070	+3.397	.001	.001	3	12
BONE	Regulation of intracellular protein transport →	+0.068	+3.413	.002	.006	3	12
SKIN	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.072	+2.936	<.001	<.001	3	12
BONE	Organic cation transport →	-0.054	-3.050	.007	.003	3	10
STOMACH	Regulation of protein localization to mitochondrion →	+0.117	+1.833	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,077 associations by consensus.

Regulation of intracellular transport by PTN expression — BONE

Explore this box plot interactively →