Across TCGA patient cohorts, PTMA mutation is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTMA-associated genes across cancer lineages are MIR4431, MTATP6P29, and RNU6ATAC17P. Each is linked with PTMA in more than 1 cancer types. Because this analysis shows association rather than direction, both PTMA-to-partner and partner-to-PTMA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTMA→partner) and Y-score (partner→PTMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4431 →	+0.282	+7.930	<.001	.008	3	2
UCEC	MTATP6P29 →	+0.213	+2.433	<.001	.009	3	2
UCEC	RNU6ATAC17P →	+0.247	+2.486	<.001	.008	3	2
UCEC	RNA5SP412 →	+0.485	+2.452	.003	.001	3	1
LIHC	TRAJ8 →	+0.700	+5.447	<.001	.005	3	1
LIHC	FAM204CP →	+0.086	+5.878	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

Exploration

PTMA survival (RNA) · tumor vs normal (RNA) · all PTMA data types