Across TCGA pan-cancer cohorts, PTMA RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PTMA’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where PTMA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTMA is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
COAD, KICH, and LIHC are the cancer types where PTMA tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTMA RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.