Across TCGA patient cohorts, PTMA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTMA-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with PTMA in more than 1 cancer types. Because this analysis shows association rather than direction, both PTMA-to-partner and partner-to-PTMA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTMA→partner) and Y-score (partner→PTMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.279	-2.000	.013	.032	3	1
UCEC	eIF4E →	+0.283	+3.584	.002	.002	3	1
UCEC	A-Raf_pS299 →	-0.170	-2.700	.001	.006	3	1
UCEC	FASN →	+0.426	+2.999	.016	.035	3	1
UCEC	MEK1 →	+0.449	+2.700	.006	.006	3	1
UCEC	p62 Lck ligand →	+0.542	+2.469	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

PTMA survival (RNA) · tumor vs normal (RNA) · all PTMA data types