Across TCGA cell cohorts, PTMA RNA expression is significantly associated with the go_rna of many other GO terms, with 5,046 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTMA-associated GO terms across cancer lineages are DNA replication initiation, Double-strand break repair via break-induced replication, and DNA replication checkpoint signaling. Each is linked with PTMA in more than 14 cancer types. Because this analysis shows association rather than direction, both PTMA-to-partner and partner-to-PTMA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTMA→partner) and Y-score (partner→PTMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.129	+0.511	.002	.003	2	15
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.243	+1.198	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.188	+1.179	<.001	<.001	3	13
KIDNEY	Spindle elongation →	+0.193	+0.747	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.144	+1.034	<.001	<.001	3	12
BONE	DNA-templated DNA replication →	+0.102	+0.557	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,046 associations by consensus.

Exploration

PTMA survival (RNA) · tumor vs normal (RNA) · all PTMA data types