PTK7

Across TCGA pan-cancer cohorts, PTK7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTK7 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PTK7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTK7 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where PTK7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.649	0.932	.004	33	view →
HNSC	OS	Tertile	IV	0.539	0.895	.007	20	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	19	view →
GBM	DFS	Quartile	All	0.545	0.303	.024	2	view →
LSCC	DFS	Quartile	All	0.419	1.000	.040	2	view →
LUAD	OS	Quartile	III,IV	1.000	0.254	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTK7–PDAC (DFS)

Open the PDAC breakdown →