PTK7

Across TCGA pan-cancer cohorts, PTK7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PTK7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTK7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTK7 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where PTK7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTK7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.305	<.001	12	view →
COAD	Female	All	+2.293	<.001	12	view →
KIRC	Male	III,IV	−0.818	<.001	11	view →
BLCA	All	III,IV	+1.720	<.001	10	view →
LIHC	Female	II,III,IV	+2.121	<.001	8	view →
BRCA	All	II,III,IV	+0.992	<.001	8	view →
KICH	Female	All	−1.566	<.001	7	view →
STAD	Male	II,III,IV	+2.192	<.001	6	view →
LUSC	Female	All	+1.296	<.001	6	view →
CHOL	Male	All	+3.751	<.001	5	view →
READ	All	All	+1.750	<.001	5	view →
LUAD	Female	All	+0.606	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PTK7–HNSC

Open the HNSC breakdown →