PTK7

Across TCGA patient cohorts, PTK7 mutation is significantly associated with the RNA expression of many other genes, with 4,377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTK7-associated genes across cancer lineages are MCAT, POLE2, and EIF2B2. Each is linked with PTK7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTK7-to-partner and partner-to-PTK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCAT grouped by PTK7-low versus PTK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK7→partner) and Y-score (partner→PTK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCAT →	+0.385	+3.042	.001	<.001	3	3
UCEC	POLE2 →	+0.507	+2.928	.001	<.001	3	3
UCEC	EIF2B2 →	+0.416	+3.627	<.001	.001	3	3
UCEC	HELLS →	+0.479	+2.823	.005	.001	3	3
UCEC	PIMREG →	+0.675	+1.895	.002	.001	3	3
UCEC	DTL →	+0.651	+3.711	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,377 associations by consensus.

MCAT by PTK7 expression — UCEC

Explore this box plot interactively →