PTK7

Across TCGA patient cohorts, PTK7 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTK7-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and MEK1. Each is linked with PTK7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTK7-to-partner and partner-to-PTK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PTK7-low versus PTK7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK7→partner) and Y-score (partner→PTK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.075	+2.178	.003	.035	3	3
COAD	14-3-3_beta →	-0.197	-3.296	.040	.010	3	2
UCEC	MEK1 →	+0.381	+2.321	.003	.005	3	2
COAD	Akt_pT308 →	+0.618	+3.330	<.001	.005	3	2
COAD	PDCD4 →	-0.395	-3.000	.046	.035	3	2
SKCM	A-Raf_pS299 →	+0.142	+1.597	.006	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by PTK7 expression — COAD

Explore this box plot interactively →