PTK7

Across TCGA cell cohorts, PTK7 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTK7-associated genes across cancer lineages are IQCF5, OR6K6, and CD300H. Each is linked with PTK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTK7-to-partner and partner-to-PTK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by PTK7-low versus PTK7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK7→partner) and Y-score (partner→PTK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IQCF5 →	+0.116	+4.643	<.001	.005	3	2
SKIN	OR6K6 →	+0.022	+4.415	<.001	.007	3	2
LARGE_INTESTINE	CD300H →	+0.018	+2.830	<.001	.004	3	2
BLOOD_Lymphoma	BMP15 →	+0.029	+4.643	<.001	.005	3	1
SKIN	PAX4 →	+0.025	+4.467	<.001	.004	3	1
OVARY	MS4A10 →	+0.012	+5.781	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

IQCF5 by PTK7 expression — BLOOD_Lymphoma

Explore this box plot interactively →