PTK7

Across TCGA cell cohorts, PTK7 mutation is significantly associated with the mutation status of many other genes, with 3,876 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTK7-associated genes across cancer lineages are HYOU1, UBR2, and NUP214. Each is linked with PTK7 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTK7-to-partner and partner-to-PTK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HYOU1 grouped by PTK7-low versus PTK7-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK7→partner) and Y-score (partner→PTK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HYOU1 →	+5.000	+4.044	.008	.008	1	6
BLOOD_Lymphoma	UBR2 →	+4.584	+4.584	.007	.007	1	5
BREAST	NUP214 →	+4.297	+4.857	.009	.009	1	5
OVARY	KIAA0232 →	+4.977	+4.415	.007	.007	1	5
OVARY	ZNF777 →	+4.977	+4.415	.007	.007	1	5
BLOOD_Leukemia	ARFGEF2 →	+4.083	+4.083	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,876 associations by consensus.

HYOU1 by PTK7 expression — CNS

Explore this box plot interactively →