PTK6

Across TCGA pan-cancer cohorts, PTK6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PTK6 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTK6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PTK6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where PTK6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.912	0.782	.011	38	view →
UCEC	DFS	Tertile	All	1.000	0.796	.036	6	view →
LUAD	DFS	Median	All	0.531	0.896	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PTK6–HNSC (OS)

Open the HNSC breakdown →