PTK6

Across TCGA pan-cancer cohorts, PTK6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PTK6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PTK6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTK6 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

LUAD, THCA, and BRCA are the cancer types where PTK6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTK6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+1.514	<.001	8	view →
THCA	Male	All	+0.431	<.001	8	view →
BRCA	All	III,IV	+1.822	<.001	6	view →
BLCA	Male	All	+2.790	.007	5	view →
CHOL	All	All	+2.237	<.001	5	view →
KICH	All	All	−1.086	<.001	5	view →
COAD	Female	All	−0.642	.002	5	view →
PAAD	Female	All	+3.779	.008	4	view →
LUSC	Male	All	+0.943	<.001	3	view →
HNSC	Female	All	−0.705	.029	3	view →
UCEC	All	All	+0.753	.007	2	view →
KIRC	Male	All	+0.309	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PTK6–LUAD

Open the LUAD breakdown →