PTK6

Across TCGA cell cohorts, PTK6 mutation is significantly associated with the mutation status of many other genes, with 3,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTK6-associated genes across cancer lineages are LGALS3BP, SLC4A9, and ACVR1B. Each is linked with PTK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTK6-to-partner and partner-to-PTK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS3BP grouped by PTK6-low versus PTK6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK6→partner) and Y-score (partner→PTK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGALS3BP →	+6.560	+6.560	<.001	<.001	1	3
BLOOD_Leukemia	SLC4A9 →	+3.823	+4.430	.001	.001	1	3
BLOOD_Leukemia	ACVR1B →	+5.145	+5.145	<.001	<.001	1	3
LARGE_INTESTINE	HS6ST1 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	KCNF1 →	+3.350	+4.584	.003	.003	1	3
BLOOD_Leukemia	ZNF559 →	+4.560	+4.309	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,120 associations by consensus.

LGALS3BP by PTK6 expression — BLOOD_Leukemia

Explore this box plot interactively →