PTK2B

Across TCGA cell cohorts, PTK2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,456 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTK2B-associated GO terms across cancer lineages are Activation of Janus kinase activity, Bone resorption, and Small GTPase-mediated signal transduction. Each is linked with PTK2B in more than 13 cancer types. Because this analysis shows association rather than direction, both PTK2B-to-partner and partner-to-PTK2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Activation of Janus kinase activity grouped by PTK2B-low versus PTK2B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2B→partner) and Y-score (partner→PTK2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Activation of Janus kinase activity →	+1.230	+1.689	<.001	.001	3	14
OESOPHAGUS	Bone resorption →	+0.126	+1.782	<.001	<.001	3	14
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.089	+1.909	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Response to tumor necrosis factor →	+0.085	+1.648	.009	.001	3	11
URINARY_TRACT	Positive regulation of iron ion transport →	+1.288	+1.921	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.288	+1.921	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,456 associations by consensus.

Activation of Janus kinase activity by PTK2B expression — LUNG_SCLC

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