PTK2B

Across TCGA pan-cancer cohorts, PTK2B RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PTK2B data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PTK2B RNA is associated with better overall survival. In most high-consensus cancer types, elevated PTK2B expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

SKCM, THCA, and CESC are the cancer types where PTK2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.432	0.277	<.001	132	view →
THCA	DFS	Median	All	0.969	0.537	<.001	81	view →
CESC	OS	Tertile	All	0.763	0.458	<.001	74	view →
BLCA	OS	Quartile	III,IV	0.757	0.548	.007	55	view →
LGG	OS	Median	All	0.736	0.884	<.001	48	view →
HNSC	DFS	Median	IV	0.505	0.251	.002	40	view →
SARC	OS	Tertile	All	0.829	0.605	<.001	25	view →
LAML	DFS	Quartile	All	0.437	0.763	.004	22	view →
LUAD	OS	Tertile	II,III,IV	0.715	0.462	.009	22	view →
UCS	DFS	Quartile	II,III,IV	0.589	0.138	.008	20	view →
MESO	OS	Median	All	0.465	0.303	.014	15	view →
SCLC	DFS	Quartile	II,III,IV	0.793	0.447	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PTK2B–SKCM (OS)

Open the SKCM breakdown →