PTK2B

Across TCGA cell cohorts, PTK2B mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTK2B-associated genes across cancer lineages are OR5C1, FRG2C, and OTOP1. Each is linked with PTK2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PTK2B-to-partner and partner-to-PTK2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5C1 grouped by PTK2B-low versus PTK2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2B→partner) and Y-score (partner→PTK2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR5C1 →	+0.038	+3.455	<.001	.002	3	2
BLOOD_Leukemia	FRG2C →	+0.481	+3.812	<.001	.004	3	2
URINARY_TRACT	OTOP1 →	+0.210	+5.087	<.001	.004	3	1
LARGE_INTESTINE	IRX4 →	+0.467	+3.409	<.001	.009	3	1
LARGE_INTESTINE	UTF1 →	+0.019	+3.632	<.001	<.001	3	1
LARGE_INTESTINE	HBG1 →	+0.105	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

OR5C1 by PTK2B expression — BLOOD_Leukemia

Explore this box plot interactively →