PTHLH

Across TCGA patient cohorts, PTHLH protein abundance is significantly associated with the RNA expression of many other genes, with 8,980 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTHLH-associated genes across cancer lineages are RNF125, GGA2, and CCP110. Each is linked with PTHLH in more than 1 cancer types. Because this analysis shows association rather than direction, both PTHLH-to-partner and partner-to-PTHLH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTHLH versus RNF125 in HNSC, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTHLH→partner) and Y-score (partner→PTHLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF125 →	-0.731	-1.166	<.001	.002	3	2
HNSC	GGA2 →	-0.739	-1.468	.005	.001	3	2
HNSC	CCP110 →	-0.555	-1.232	.003	.003	3	2
HNSC	NDRG1 →	+1.504	+1.381	<.001	<.001	3	2
HNSC	MAP4K1 →	-0.883	-1.620	.006	<.001	3	2
HNSC	CD37 →	-1.052	-2.287	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,980 associations by consensus.

PTHLH vs RNF125 — HNSC

Explore this scatter interactively →