PTHLH

Across TCGA patient cohorts, PTHLH mutation is significantly associated with the RNA expression of many other genes, with 1,044 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTHLH-associated genes across cancer lineages are MIR6864, UHRF1, and SFRP1. Each is linked with PTHLH in more than 2 cancer types. Because this analysis shows association rather than direction, both PTHLH-to-partner and partner-to-PTHLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6864 grouped by PTHLH-low versus PTHLH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTHLH→partner) and Y-score (partner→PTHLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR6864 →	+0.638	+2.798	.001	.005	3	3
UCEC	UHRF1 →	+0.809	+2.595	.001	<.001	3	2
UCEC	SFRP1 →	-1.440	-2.584	<.001	.001	3	2
UCEC	TLE6 →	+0.777	+2.606	.001	<.001	3	2
UCEC	BAG1 →	+0.591	+3.818	<.001	<.001	3	2
UCEC	TPI1 →	+0.505	+3.740	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,044 associations by consensus.

MIR6864 by PTHLH expression — COAD

Explore this box plot interactively →