PTH2R

Across TCGA pan-cancer cohorts, PTH2R Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTH2R data layer compared with 23 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PTH2R Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PTH2R expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, LIHC, and UCEC are the cancer types where PTH2R Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
UCEC	DFS	Median	All	0.950	0.627	.021	12	view →
PRAD	OS	Median	All	0.080	0.990	<.001	12	view →
LUAD	OS	Median	III,IV	0.167	0.690	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PTH2R–THYM (OS)

Open the THYM breakdown →