PTH1R

Across TCGA patient cohorts, PTH1R mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTH1R-associated genes across cancer lineages are Rad50, ASNS, and ATM. Each is linked with PTH1R in more than 2 cancer types. Because this analysis shows association rather than direction, both PTH1R-to-partner and partner-to-PTH1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by PTH1R-low versus PTH1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH1R→partner) and Y-score (partner→PTH1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.253	-2.321	.005	.005	3	3
UCEC	ASNS →	+0.460	+1.700	<.001	.042	3	2
UCEC	ATM →	-0.345	-2.308	.042	.033	3	2
UCEC	4E-BP1 →	+0.291	+3.459	.004	.005	3	2
UCEC	C-Raf →	+0.171	+2.222	.001	.010	3	2
UCEC	eIF4E →	+0.172	+1.765	.030	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rad50 by PTH1R expression — UCEC

Explore this box plot interactively →