PTH1R

Across TCGA cell cohorts, PTH1R mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTH1R-associated genes across cancer lineages are GSG1L2, CLDN17, and BPIFB6. Each is linked with PTH1R in more than 1 cancer types. Because this analysis shows association rather than direction, both PTH1R-to-partner and partner-to-PTH1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by PTH1R-low versus PTH1R-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH1R→partner) and Y-score (partner→PTH1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	KLK9 →	+0.159	+3.878	<.001	.003	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GSG1L2 by PTH1R expression — BLOOD_Leukemia

Explore this box plot interactively →