PTGS2

Across TCGA patient cohorts, PTGS2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGS2-associated genes across cancer lineages are JNK2, MAPK_pT202_Y204, and p90 RSK_pT359_S363. Each is linked with PTGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGS2-to-partner and partner-to-PTGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PTGS2-low versus PTGS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGS2→partner) and Y-score (partner→PTGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.191	+1.938	.003	.001	3	2
UCEC	MAPK_pT202_Y204 →	-0.369	-2.102	.017	.016	3	2
UCEC	p90 RSK_pT359_S363 →	-0.161	-1.700	.015	.040	3	2
UCEC	TFRC →	+0.512	+2.459	.003	.018	3	2
UCEC	TIGAR →	+0.132	+1.418	.008	.012	3	2
UCEC	ATM →	-0.437	-2.209	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

JNK2 by PTGS2 expression — UCEC

Explore this box plot interactively →