PTGS2

Across TCGA pan-cancer cohorts, PTGS2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PTGS2 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PTGS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTGS2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and PRAD show a favorable association.

UVM, ACC, and THCA are the cancer types where PTGS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.426	0.908	<.001	158	view →
ACC	OS	Tertile	All	0.709	0.932	.001	43	view →
THCA	DFS	Median	III,IV	0.861	0.979	.006	25	view →
KIRC	DFS	Median	III,IV	0.678	0.817	.018	23	view →
BLCA	DFS	Quartile	III,IV	0.441	0.180	.010	21	view →
STAD	DFS	Quartile	All	0.572	0.731	.005	18	view →
THYM	DFS	Quartile	All	0.813	0.970	.010	14	view →
CESC	DFS	Tertile	All	0.650	0.810	.005	14	view →
PRAD	DFS	Tertile	All	0.968	0.892	.006	14	view →
ESCA	DFS	Tertile	IV	0.242	0.692	.024	12	view →
KIRP	DFS	Median	II,III,IV	0.477	0.808	.008	11	view →
LUAD	OS	Tertile	All	0.786	0.876	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PTGS2–UVM (OS)

Open the UVM breakdown →