PTGS2

Across TCGA cell cohorts, PTGS2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTGS2-associated genes across cancer lineages are IL36B, PROP1, and CST9L. Each is linked with PTGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGS2-to-partner and partner-to-PTGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36B grouped by PTGS2-low versus PTGS2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGS2→partner) and Y-score (partner→PTGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL36B →	+0.032	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PROP1 →	+0.012	+4.867	.001	.009	3	1
SOFT_TISSUE	CST9L →	+0.021	+4.369	<.001	.008	3	1
SOFT_TISSUE	CD40LG →	+0.038	+4.222	<.001	.007	3	1
SOFT_TISSUE	RETNLB →	+0.078	+4.369	<.001	.008	3	1
SOFT_TISSUE	C8orf74 →	+0.022	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

IL36B by PTGS2 expression — BLOOD_Lymphoma

Explore this box plot interactively →