PTGES2

Across TCGA patient cohorts, PTGES2 mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGES2-associated genes across cancer lineages are RN7SL478P, DUX4L47, and ALDH7A1P2. Each is linked with PTGES2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGES2-to-partner and partner-to-PTGES2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL478P grouped by PTGES2-low versus PTGES2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES2→partner) and Y-score (partner→PTGES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL478P →	+0.241	+4.975	<.001	.002	3	2
CESC	DUX4L47 →	+0.111	+4.539	<.001	.008	3	2
BLCA	ALDH7A1P2 →	+0.074	+5.038	<.001	.009	3	2
BRCA	RNY3P11 →	+0.315	+4.683	<.001	.007	3	2
BRCA	MFSD4BP1 →	+0.039	+4.800	.004	.006	3	2
UCEC	RNA5SP463 →	+0.627	+2.521	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

RN7SL478P by PTGES2 expression — BRCA

Explore this box plot interactively →