PTGES2

Across TCGA cell cohorts, PTGES2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTGES2-associated genes across cancer lineages are HAO1, PRLHR, and OOSP2. Each is linked with PTGES2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGES2-to-partner and partner-to-PTGES2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAO1 grouped by PTGES2-low versus PTGES2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES2→partner) and Y-score (partner→PTGES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HAO1 →	+0.052	+3.242	<.001	.003	3	1
SKIN	PRLHR →	+0.008	+3.700	<.001	.009	3	1
SKIN	OOSP2 →	+0.006	+3.217	.002	.006	3	1
SKIN	OR10J5 →	+0.011	+3.700	<.001	.009	3	1
SKIN	OR51M1 →	+0.062	+3.974	.002	.002	3	1
SKIN	ANKRD66 →	+0.012	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

HAO1 by PTGES2 expression — SKIN

Explore this box plot interactively →