PTGES

Across TCGA patient cohorts, PTGES mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGES-associated genes across cancer lineages are RNA5SP414, MIR7702, and RNA5SP411. Each is linked with PTGES in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGES-to-partner and partner-to-PTGES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by PTGES-low versus PTGES-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES→partner) and Y-score (partner→PTGES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+1.807	+4.577	<.001	<.001	3	1
UCEC	MIR7702 →	+0.537	+5.738	<.001	<.001	3	1
UCEC	RNA5SP411 →	+3.161	+4.978	<.001	<.001	3	1
UCEC	RNA5SP412 →	+1.652	+4.289	<.001	<.001	3	1
UCEC	MIR6854 →	+0.316	+4.260	<.001	.007	3	1
UCEC	RNA5SP124 →	+0.628	+2.996	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RNA5SP414 by PTGES expression — UCEC

Explore this box plot interactively →