PTGES

Across TCGA pan-cancer cohorts, PTGES RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PTGES’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PTGES RNA is repressed in tumor relative to normal tissue. In most cancer types PTGES is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where PTGES tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTGES RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.911	<.001	11	view →
COAD	Male	III,IV	+2.018	<.001	10	view →
LUAD	Female	III,IV	+3.043	<.001	9	view →
LUSC	Male	II,III,IV	+2.284	<.001	8	view →
LIHC	All	II,III,IV	+1.718	.001	6	view →
CHOL	All	All	+3.270	<.001	5	view →
READ	All	All	+1.599	.010	4	view →
KIRP	All	II,III,IV	+1.043	.021	4	view →
STAD	All	All	+0.685	.019	4	view →
HNSC	All	All	+0.796	.002	3	view →
PAAD	All	All	+2.527	.025	2	view →
ESCA	All	All	+1.714	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PTGES–KIRC

Open the KIRC breakdown →