PTGES

Across TCGA cell cohorts, PTGES RNA expression is significantly associated with the go_rna of many other GO terms, with 4,057 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PTGES-associated GO terms across cancer lineages are Regulation of fever generation, Regulation of heat generation, and Interleukin-10-mediated signaling pathway. Each is linked with PTGES in more than 13 cancer types. Because this analysis shows association rather than direction, both PTGES-to-partner and partner-to-PTGES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fever generation grouped by PTGES-low versus PTGES-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES→partner) and Y-score (partner→PTGES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of fever generation →	+1.805	+3.445	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of heat generation →	+1.195	+3.032	<.001	<.001	3	12
SOFT_TISSUE	Interleukin-10-mediated signaling pathway →	+0.202	+1.846	<.001	<.001	3	10
BREAST	Negative regulation of immune response →	+0.081	+2.527	.001	<.001	3	10
OVARY	Lactose metabolic process →	+0.202	+2.530	<.001	<.001	3	10
STOMACH	Type II interferon-mediated signaling pathway →	+0.259	+4.407	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,057 associations by consensus.

Regulation of fever generation by PTGES expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →