PTGER3

Across TCGA patient cohorts, PTGER3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGER3-associated genes across cancer lineages are PCNA, CDK1, and Cyclin-B1. Each is linked with PTGER3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGER3-to-partner and partner-to-PTGER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PTGER3-low versus PTGER3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER3→partner) and Y-score (partner→PTGER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.208	+1.263	.001	.019	3	3
UCEC	CDK1 →	+0.117	+1.428	.011	.025	3	3
UCEC	Cyclin-B1 →	+0.564	+2.222	.001	.009	3	3
LUSC	Shc_pY317 →	-0.162	-2.276	.031	.035	3	2
UCEC	eEF2 →	+0.252	+1.678	.021	.021	3	2
COAD	eIF4E →	+0.190	+2.182	.008	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PCNA by PTGER3 expression — UCEC

Explore this box plot interactively →