PTGDS

Across TCGA pan-cancer cohorts, PTGDS Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTGDS data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTGDS Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PTGDS expression acts as an unfavorable survival marker.

HNSC, OV, and CESC are the cancer types where PTGDS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.197	0.753	<.001	48	view →
OV	OS	Median	II,III,IV	0.118	0.844	<.001	36	view →
CESC	OS	Median	All	0.455	0.800	<.001	24	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PTGDS–HNSC (OS)

Open the HNSC breakdown →