PTEN

Across TCGA pan-cancer cohorts, PTEN Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated PTEN data layer compared with 21 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PTEN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PTEN expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

MESO, KICH, and ESCA are the cancer types where PTEN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	IV	0.056	0.640	<.001	66	view →
KICH	DFS	Median	II,III,IV	0.086	0.793	<.001	33	view →
ESCA	DFS	Median	II,III,IV	0.104	0.530	<.001	30	view →
UCS	DFS	Median	III,IV	0.122	0.465	.003	24	view →
UCEC	DFS	Median	All	0.810	0.556	.006	22	view →
READ	OS	Median	IV	0.111	0.893	<.001	15	view →
LGG	OS	Median	All	0.467	0.823	<.001	14	view →
CESC	OS	Median	IV	0.207	0.635	.006	6	view →
STAD	OS	Median	IV	0.111	0.433	.002	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUSC	OS	Median	All	0.933	0.763	.014	3	view →
COAD	DFS	Median	All	0.942	0.775	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

PTEN–MESO (OS)

Open the MESO breakdown →