PTEN

Across TCGA pan-cancer cohorts, PTEN mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PTEN data layer compared with 21 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PTEN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTEN expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, COAD, and UCEC are the cancer types where PTEN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.757	0.455	.005	20	view →
COAD	DFS	Median	II,III,IV	0.895	1.000	.036	12	view →
UCEC	DFS	Quartile	II,III,IV	0.507	1.000	.021	10	view →
PDAC	OS	Median	IV	0.937	0.395	.026	6	view →
LSCC	DFS	Quartile	II,III,IV	0.784	1.000	.013	6	view →
GBM	DFS	Tertile	All	0.445	0.252	.011	5	view →
HNSC	DFS	Tertile	IV	0.465	0.759	.028	4	view →
LUAD	OS	Tertile	III,IV	0.723	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PTEN–CCRCC (DFS)

Open the CCRCC breakdown →